Chelsea will face Swedish side Malmo in the last 32 of the Europa League, while Arsenal have been paired with Belarusian outfit BATE Borisov.
Scottish champions Celtic will take in a tricky test against La Liga heavyweights Valencia.
Other notable ties include Lazio locking horns with Sevilla and Galatasaray taking on Benfica.
Europa League last 32 draw in full:
Viktoria Plzen vs Dinamo Zagreb
Club Brugge vs Red Bull Salzburg
Rapid Wien vs Inter
Slavia Prague vs Genk
Krasnodar vs Bayer Leverkusen
FC Zurich vs Napoli
Malmo vs Chelsea
Shakhtar Donetsk v Eintracht Frankfurt
Celtic vs Valencia
Rennes vs Real Betis
Olympiacos vs Dynamo Kiev
Lazio vs Sevilla
Fenerbahce vs Zenith
Bate vs Arsenal